Lucy and The Ghoul form an uneasy alliance to track down Lucy’s father, Hank, who was last seen fleeing toward the iconic, neon-lit remains of New Vegas. As they navigate this dangerous new territory, they encounter legendary factions from the games, including Caesar’s Legion and the NCR, while the shadow of the enigmatic Mr. House looms over the city's future. Meanwhile, back at the Brotherhood of Steel, Maximus grapples with his rising status and the faction's growing fanaticism, and Norm MacLean uncovers even darker conspiracies hidden within the frozen chambers of Vault 31.