Sam enlists everyone's help in trying to track down Dean, who can literally be anywhere. Meanwhile, Castiel may be in over his head after meeting up with an unreliable source. After being drained of his grace, Jack is adjusting to life as a human, learning new skills and figuring out how he fits in to this world of hunters.

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Sam finds a clue to Dean's whereabouts, so he, Mary and Bobby set out to investigate. Castiel imparts some sage advice on Jack, who, still desperate to belong, seeks out a familial connection.

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Still trying to solve the mystery of what happened to Dean, Sam enlists the help of Sheriff Jody Mills who may unknowingly already be on the case. Castiel continues to be a father figure to Jack, who surprises even himself, when a life is on the line.

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Dean continues to struggle, and then Sam has to think when action figures come to life and Dean finds himself inside a real life horror movie.

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Sam and Castiel track down a Shaman who may be able to help a friend. Nick continues to spiral down a dark path as he looks for answers surrounding the deaths of his wife and son. Jack turns to Dean for help enjoying the human experience.

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When Dean and Sam join forces with an unexpected ally, the outcome will alter the course of two lives. Meanwhile, Heaven faces an attack from a dark force, driving Castiel to make an enormous sacrifice to make things right.

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Sam and Dean enlist the help of their pal Garth to gain inside information on what Michael may be planning. The brothers split up to each go after weapons that can aid in their fight against the Archangel, but this may be a fight our heroes cannot win.

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Michael retakes control of Dean as his army of monsters continue to move in; Sam devises a plan to reach Dean and stop Michael before anyone else dies.

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Dean spends some bonding time with Mary and Donna. Nick finally finds the answer he has been searching for. Sam is left to make an unimaginable choice.

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Sam and Dean must figure out how to stop the bloodshed when Donatello who, in his current condition, is inadvertently scrambling the order of future prophets. Nick comes face to face with his past.

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Sam and Dean look to occult lore for a solution to their latest problem, but instead of a resolution, they find much more than either of them had anticipated.

This is the 300th episode.

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Sam and Dean enlist the help of Rowena to track down a demi-god who feasts on human flesh; the challenge of keeping Michael at bay is proving to be more difficult than originally anticipated.

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Sam and Dean race to help a friend in need. Meanwhile, Mary is concerned for Jack's wellbeing, and Castiel enlists help from Jo/Anael to track down a miracle.

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Sam and Dean continue to worry about the condition of Jack's soul.

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Sam, Dean and Castiel investigate a string of suspicious deaths that have a biblical element to them.

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Sam, Dean and Castiel are thrown into an epic battle. Meanwhile, Jack becomes disenchanted with all the lies, and an old friend from the past shows up.

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