After a severe accident, Cliff Steele wakes up, a changed man, in the house of Dr. Niles Caulder and his Doom Patrol.

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The Chief has disappeared and the only clue that the team has to his whereabouts is an average donkey.

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The Doom Patrol set out for Paraguay where they discover the Nazi doctor who created Mr. Nobody and the connection between the Chief and the two villains.

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Willoughby Kipling conscripts the Doom Patrol into helping him avert the end of the world by stopping a nihilistic cult.

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Mr. Nobody decides to interfere with the Decreator's prophecy with the help of Niles Caulder.

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Cliff and Victor come to an agreement while Jane, Rita, and Larry go in search of a mysterious team called the Doom Patrol.

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After a violent outburst from Cliff, the team engages in some self-led group therapy - leading to some growth within the group as they are knit closer together.

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A sentient, gender-queer, teleporting street, named Danny is being hunted by the secret Bureau of Normalcy and needs help from Niles - but gets Vic and Larry instead.

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Jane retreats into a treacherous place in her own mind called The Underground, where she encounters her many personas and dark traumas from her past.

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Vic and Rita face a dangerous man known as the Beard Hunter, who has been activated by the Bureau of Normalcy to find Niles Caulder.

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Larry pays a visit to his long lost-love, while Cliff and Rita travel to Gator Country to reconnect with his daughter. Vic worries about his operating system.

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Silas and the team break into the Ant Farm to rescue Victor.

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Rita tries to soothe Victor during a difficult time while the rest of the team finds Flex Mentallo and tries to help him regain his memory.

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The group prepares for one last stand against Mr. Nobody and rescue the Chief. Victor learns a hard truth.

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The team tries to cope with a hard truth as Mr. Nobody prepares for his final act of vengeance.

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