Eliza comes to town to celebrate Thanksgiving with her daughters. Alex decides it's time to come out to her mother; Kara is shocked when Eliza suggests Mon-El has feelings for her, and Winn and James consider telling Kara the truth about the Guardian. Meanwhile, Cadmus unleashes a virus that instantly kills any alien in the vicinity so Kara enlists an unexpected ally - Lena Luthor.

(Technically not part of the crossover, but it contains one short teaser scene that is later used in the actual Invasion! crossover event).

When aliens called the Dominators attack Central City, Barry speeds over to Star City to ask the Green Arrow for help in stopping them. Realizing the battle against the Dominators is bigger than they thought, they track down the Legends of Tomorrow, and Barry and Cisco create a breach to bring back a secret weapon – Supergirl. 

Oliver wakes up to a life where he never got on The Queen's Gambit. Robert and Moira are alive and well. Laurel is his loving fiancée and their wedding is imminent. Everything seems perfect, but Oliver starts to notice small imperfections that make him question this new reality. Meanwhile, Felicity and the recruits take on a new threat with help from The Flash and Supergirl.

After learning the Dominators' plan for the world, the Legends must work together with The Flash, Supergirl and Green Arrow to kill them once and for all. Meanwhile, Stein figures out, with the help of others, how the team can terminate the Dominators, but is distracted by the aberration he realizes he created in 1987.