After a severe accident, Cliff Steele wakes up, a changed man, in the house of Dr. Niles Caulder and his Doom Patrol.

The Chief has disappeared and the only clue that the team has to his whereabouts is an average donkey.

The Doom Patrol set out for Paraguay where they discover the Nazi doctor who created Mr. Nobody and the connection between the Chief and the two villains.

Willoughby Kipling conscripts the Doom Patrol into helping him avert the end of the world by stopping a nihilistic cult.

Mr. Nobody decides to interfere with the Decreator's prophecy with the help of Niles Caulder.

Cliff and Victor come to an agreement while Jane, Rita, and Larry go in search of a mysterious team called the Doom Patrol.

After a violent outburst from Cliff, the team engages in some self-led group therapy - leading to some growth within the group as they are knit closer together.

A sentient, gender-queer, teleporting street, named Danny is being hunted by the secret Bureau of Normalcy and needs help from Niles - but gets Vic and Larry instead.

Jane retreats into a treacherous place in her own mind called The Underground, where she encounters her many personas and dark traumas from her past.

Vic and Rita face a dangerous man known as the Beard Hunter, who has been activated by the Bureau of Normalcy to find Niles Caulder.

Larry pays a visit to his long lost-love, while Cliff and Rita travel to Gator Country to reconnect with his daughter. Vic worries about his operating system.

Silas and the team break into the Ant Farm to rescue Victor.

Rita tries to soothe Victor during a difficult time while the rest of the team finds Flex Mentallo and tries to help him regain his memory.

The group prepares for one last stand against Mr. Nobody and rescue the Chief. Victor learns a hard truth.

The team tries to cope with a hard truth as Mr. Nobody prepares for his final act of vengeance.