Daisy has left S.H.I.E.L.D. and is trying to solve the mystery of a bunch of serial killings in the Los Angeles area. At the same time her old friends suspect her for the killings and are following her trail in an attempt to find her.

Daisy goes to battle Ghost Rider at a terrible cost, and Coulson faces the new director, whose bold agenda surprises them all.

Coulson, Mack and Fitz try to locate and neutralize a rogue group looking to stop Inhuman registration worldwide; Simmons and Dr. Radcliffe have only a short time to save May before she succumbs to her illness.

As Ghost Rider's quest for vengeance brings him into an explosive confrontation with S.H.I.E.L.D., Coulson and Mack must rely on an unlikely ally in their time of desperate need; and Daisy reunites with a familiar face to stop the Watchdogs.

As Robbie Reyes struggles to control The Ghost Rider, S.H.I.E.L.D. infiltrates a high-security prison to unravel the secrets that haunt them all.

The shocking origin story of Robbie's transition into Ghost Rider is revealed as the lives of Coulson and the team hang in the balance.

With the loss of half the team, the remaining members search for answers as the clock counts down for Ghost Rider.

With the lives of everyone in Los Angeles hanging in the balance, S.H.I.E.L.D. and Ghost Rider find themselves working together.

Though Coulson and May are growing closer, Coulson remains unaware of the dark secret May is hiding beneath the surface. Meanwhile, Aida is unrelenting in her search for the Darkhold.

Separated from their team, Coulson and Mack discover a shocking secret about Mace, leaving all of S.H.I.E.L.D. in a precarious position.

May works to uncover the truth about what happened to her; Aida's next move puts everyone's life at risk.

Dr. Radcliffe goes after the Koenig family to find the location of the Darkhold. The Superior reveals his plans to Radcliffe.

An explosive Inhuman surfaces and the team are tasked with containing it. Elsewhere: Coulson and Mack encounter Radcliffe's inspiration for Aida.

Coulson and the team engage in a deadly cat-and-mouse game as they work to rescue Director Mace, who is fighting for his life.

As Radcliffe and Aida's plan goes into action, Fitz and Simmons are trapped in the Playground unsure of which of their friends are real and which ones have been replaced by LMDs.

Daisy and Simmons uncover secrets and lies in a world gone mad. With Hydra in control, they are our only hope to save everyone.

As Daisy and Simmons struggle to discover an escape route to the real world, the identity of the Inhuman leader of the Resistance is revealed.

The truth behind Fitz's turn threatens to bring down all of S.H.I.E.L.D.

Daisy teams up with an unlikely partner; Aida prepares to put her endgame into effect.

The clock is ticking for Daisy and Simmons to get the team out of the Framework, but not everyone is ready and willing to leave.

Coulson and the team's victory in the Framework is short-lived, as an even deadlier enemy looms against them all.

With the surprising emergence of Ghost Rider, Coulson and the team attempt to stop Aida from ending the world.