Covering days one through 13, everyone at Seattle Grace fights to save Izzie and George's lives and then deals with the aftermath. Elsewhere, Hunt treats a double amputation, and Arizona has a teen with painful growth spurts.

During days 20 through 40 the staff continues toward acceptance. Meanwhile, Arizona takes a manipulative step to diagnose her pain patient and Hunt's amputee patient sinks into a deep depression.

Izzie returns to work. Seattle Grace residents position themselves to avoid lay-offs. Cristina tries to work with Arizona in the paediatric ward.